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Intratumoral expression of VEGF and the VEGFR was predominantly observed in the cytoplasm of the tumor cells. High expression of both VEGF and VEGFR was associated with positive lymph nodes (p = 0.0001 and p = 0.0007, respectively). In contrast, the expression of either VEGF or VEGFR alone was not an independent factor in predicting survival. In addition, the expression of VEGF or VEGFR alone or in combination was not associated with the clinicopathological features of the disease. Concomitant high expression of VEGF and VEGFR in colon carcinoma is associated with the number of positive nodes. These observations in stage II colon carcinoma are in agreement with the known biological role of VEGF/VEGFR in vascular permeability and lymphangiogenesis. However, in contrast to previous data in stage II colon carcinoma, high expression of VEGF or VEGFR alone or in combination as a prognostic factor was not observed in this study. 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